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Antimicrobial Resistance

Biomedica provides a comprehensive product portfolio in the field of Antimicrobial Resistance.

Antimicrobial Resistance (AMR) is the ability of a microorganism (e.g. bacterium, fungus or parasite) to resist the action of an antimicrobial agent. The World Health Organization (WHO) has included AMR as one of the top ten threats to global health in 2019 (WHO 2019).
Today, we live in a time when more and more diseases, including respiratory tract infections, sexually transmitted infections and urinary tract infections, do not respond to drug treatment and life-saving medical procedures are becoming much riskier due to the threat of untreatable infections.
The selective pressure created by the broad use of antibiotics in agriculture, livestock, veterinary and human medical practices has contributed to the current antibiotic resistance crisis - the expansion of multidrug resistant organisms (MDROs) on a global level.

Addressing the rising threat of AMR requires therefore a multidisciplinary approach. One Health Strategy integrates human, veterinary, but also environmental, aquatic, and wildlife issues into current approaches.
AMR is a global crisis. There is no time to wait.

Antimicrobial Susceptibility Testing

  • Automated and customized susceptibility testing
    MICRONAUT-S Detection of resistance mechanisms
    MICRONAUT-S Anaerobes MIC

Molecular Assays for Active MDRO Screening

  • MRSA- methicillin-resistant Staphylococcus aureus carriage

    Accurate, on-demand PCR test provides actionable results in about an hour
    Cepheid Xpert MRSA NxG
  • Pre-surgical testing of S. aureus and MRSA in about an hour
    Cepheid Xpert SA Nasal Complete
  • mecA and mecC detection in less than 100 minutes

    VRE- vancomycin-resistant Enterococci carriage

  • The first rapid and accurate test to assist with VRE surveillance
    Cepheid Xpert vanA/vanB
  • Complete information on Vancomycin-resistance - an one-step assay

    CRE- carbapenem-resistant Enterobacteriaceae

  • A qualitative, on-demand real-time PCR test for the detection and differentiation of KPC, NDM, VIM, OXA-48 and IMP in 48 minutes
    Cepheid Xpert Carba-R
  • Tracking down carbapenem-resistance – one test in less than 100 minutes
    GENSPEED Superbug CR
  • Extended detection of all the main relevant variants of KPC, NDM, VIM, IMP, and OXA-48-like genes
    Elitech ELITe CRE MGB Kit

    ESBL- Extended-Spectrum Beta-Lactamase producing bacteria carriage

  • Detection of the main relevant variants CTX-M-1 and CTX-M-9 gene families
    Elitech ELITe ESBL MGB Kit

    Colistin resistant Enterobacteriaceae colonization

  • Detection of plasmidic colistin resistance genes mcr-1 and mcr-2 of Enterobacteriaceae
    Elitech ELITe Colistin Resistance MGB Kit

Molecular Assays for Diagnosing Antibiotic Resistant Infections

Panels for diagnosis of sepsis-causing pathogens and resistance markers

  • Direct-from-blood detection of antibiotic genes associated with sepsis-causing pathogens
    T2 Resistance Panel by T2 Biosystems

Detection of MRSA infections

  • Accurate detection of MRSA and SA in positive blood culture specimens in about an hour
    Cepheid Xpert MRSA/SA BC
  • Detect MRSA and SA skin and soft tissue infections in about an hour
    Cepheid Xpert MRSA/SA SSTI

Rifampicin and Isoniazid-resistant MTB infections

  • Two-hour detection of MTB and rifampicin resistance mutations
    Xpert MTB/RIF Ultra
  • Combined with the frontline test Xpert MTB/RIF Ultra, Xpert MTB/XDR detects mutations associated with drug resistance towards Isoniazid, Fluoroquinolones, Second-Line Injectable Drugs and Ethionamide
    Xpert MTB/XDR
  • Simultaneous detection of the DNA of Mycobacterium tuberculosis complex and resistance to rifampicin and isoniazid
    Elitech ELITe MTB- Resistance MGB Kit
  • Detection and genotyping of tuberculosis variants resistant to rifampicin and isoniazid
    Diagcor GeneFlow DR-MTB Array

Clarithromycin-resistant Helicobacter pylori infections

  • Simultaneous detection of Helicobacter pylori and clarithromycin resistance
    H. pylori ClariRes Assay

Drug-resistant Sexually Transmitted Infections

  • A real-time PCR test to detect Neisseria gonorrhoeae and ciprofloxacin susceptibility markers
    SpeeDx ResistancePlus GC
  • The first molecular CE_IVD test to detect Mycoplasma genitalium and macrolide resistance markers
    SpeeDx ResistancePlus MG
  • A multiplex assay to detect and differentiate Mycoplasma genitalium and its macrolide resistance
    Elitech ELITe MG+ Resistance MGB Kit

Rapid detection of Antibiotic Resistance Markers from culture and positive blood culture

NG Biotech develops multiplex rapid tests in lateral flow format based on the use of specific monoclonal antibodies.
All tests are validated at the French National Reference Center on Antimicrobial Resistance (AMR).

  • Rapid detection of group 1 CTX-M β-lactamases (ESBL)
    NG-Test CTX-M
  • Detection of CTX-M-1, CTX-M-2, CTX-M-8, CTX-M-9 and CTX-M-25 (the main CTX-M groups) with a high negative predictive value – ideal for screening
  • Rapid detection and differentiation of KPC, OXA, VIM, IMP and NDM
    NG-Test CARBA5
  • Rapid and visual immunoassay for the detection of MCR-1 mediated colistin resistance
    NG-Test MCR-1

Complete Overview: Please Click

Quality Control in Molecular Testing for MDRO

Vircell AmpliRun are non-infectious complete genome preparations that can be used for full process control of any molecular testing.

  • AmpliRun Staphylococcus aureus mecA+ DNA control
  • AmpliRun Enterococcus faecalis (vanB) DNA control
  • AmpliRun Enterococcus faecium (vanA) DNA control
    Complete Overview: Please Click

Microbiologics Helix Elite Molecular standards are single or multi parameter molecular controls.

  • Helix Elite CRE Control Panel - Inactivated Swab. IMP, KPC-3, NDM-1, OXA-48, VIM-1, Metallo-beta-lactamase positive
  • Helix Elite MRSA - Inactivated Swab
  • Helix Elite Enterococcus faecium (vanA) positive control swabs, Enterococcus faecalis negative control swabs
  • Rifampicin-Resistant Mycobacterium tuberculosis Control Panel - Inactivated Pellet

    Complete Overview: Microbiologics_Molecular_Controls_Catalog